Extreme Physiology & Medicine is a peer-reviewed open access, online journal focussing on integrative human physiology under conditions of physiological stress, including that exerted by extreme environments, exercise and certain clinical conditions.

Editors-in-Chief

  • Mike Grocott, University of Southampton
  • Hugh Montgomery, University College London

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Editors' profiles

Dr. Leiyu Shi

Mike Grocott

Mike Grocott is the professor of anaesthesia and critical care at the University of Southampton and a consultant in critical care medicine at Southampton University Hospitals NHS Trust. He leads the Centre for Human Integrative Physiology, University of Southampton and previously co-founded and directed (2000-2011) the UCL Centre for Altitude, Space and Extreme Environment Medicine. He chairs the Caudwell Xtreme Everest Hypoxia Research Consortium and the Fit-4-Surgery Research Collaboration. He has led a number of high altitude medical research expeditions, most notably the 2007 Caudwell Xtreme Everest expedition: the largest systematic field study of hypobaric hypoxia to date, with 222 subjects studied at Everest Base Camp and physiological measurements at up to 8400 metres. He has authored more than 100 peer reviewed papers.


Efrat Shadmi

Hugh Montgomery

Hugh Montgomery is Professor of Intensive Care medicine at University College, London (UCL), where he also directs the Institute for Human Health and Performance.

His work has focussed (although not exclusively) on the use of genetic tools to understand human physiological responses to environmental stimuli, as a means to explore their dysregulation in complex disease states. He thus reported the first association of a genetic variant with human physical performance. He has since described the role of genetic variants in influencing the human cardiac, metabolic and musculoskeletal responses to exercise. In systems biology, his work has explored the roles of tissue and cellular renin-angiotensin systems in health and disease. He also has a strong interest in the human adaptive response to hypoxia- being science lead for the 2007 Caudwell Xtreme Everest Expedition, and publishing on the population genetic aspects of high-altitude adaptation. He has authored over 160 peer-reviewed papers.


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  • PubMed Central
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ISSN: 2046-7648